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2025.01.06
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日本動脈硬化学会総会プログラム・抄録集(1347-7099)56回 Page291(2024.06)
2024/11/01
医中誌文献番号:Y910360342
無症候性高尿酸血症患者に対するキサンチンオキシダーゼ阻害薬Febuxostatの白血球数への影響竹下 光英(佐賀大学 医学部循環器内科), 田中 敦史, 吉田 寿子, 野出 孝一
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日本動脈硬化学会総会プログラム・抄録集(1347-7099)56回 Page163(2024.06)
2024/11/01
医中誌文献番号:Y910360107
MASLD/MASHを背景とした脂質代謝、動脈硬化研究 肝機能障害合併・高尿酸血症患者の血管伸展性指標・CAVIに対するFebuxostatの効果(PRIZE studyのサブ解析)西澤 均(大阪大学 大学院医学系研究科内分泌・代謝内科学), 川知 祐介, 藤島 裕也, 吉田 寿子, 田中 敦史, 野出 孝一, 下村 伊一郎
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Biosens Bioelectron. 2024 Nov 9;269:116928. doi: 10.1016/j.bios.2024.116928. Online ahead of print.
2024/11/16
P-type accumulation mode organic electrochemical transistor biosensor for xanthine detection in fish
Lin Y, Kroon R, Zeglio E, Herland A.
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BMC Oral Health. 2024 Nov 15;24(1):1389. doi: 10.1186/s12903-024-05173-x.
2024/11/16
Hyperuricemia and elevated uric acid/creatinine ratio are associated with stages III/IV periodontitis: a population-based cross-sectional study (NHANES 2009-2014)
Chen Y, Lu P, Lin C, Li S, Zhu Y, Tan J, Zhou Y, Yu T.
-
Int J Biol Macromol. 2024 Nov 14;283(Pt 1):137636. doi: 10.1016/j.ijbiomac.2024.137636. Online ahead of print.
2024/11/16
The novel mechanism on the inhibition of superoxide anion generating from xanthine oxidase in the presence of myricetin
Yao Y, Ma A, Huang Q, Chen J, Yan J, Chen L, Ye J, Zhang M, Yang H, Chen S.
-
Expert Opin Drug Saf. 2024 Nov 18:1-9. doi: 10.1080/14740338.2024.2430304. Online ahead of print.
2024/11/14
Cardiovascular outcomes of urate-lowering therapies in patients with gout or hyperuricemia: a network meta-analysis
Yan Y, Bai Y, Wang J, Li G.
-
Acta Diabetol. 2024 Nov 14. doi: 10.1007/s00592-024-02376-0. Online ahead of print.
2024/11/14
J-shaped association of serum uric acid with all-cause and cardiovascular mortality in patients with diabetic kidney disease
Zhang X, Zhang Z, Gao L, Huang B, Liu Y, Cui J, Jia J, Liu M.
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CPT Pharmacometrics Syst Pharmacol. 2024 Nov 14. doi: 10.1002/psp4.13273. Online ahead of print.
2024/11/14
Artificial intelligence modeling of biomarker-based physiological age: Impact on phase 1 drug-metabolizing enzyme phenotypes
Bhat AG, Ramanathan M.
-
BMC Cardiovasc Disord. 2024 Nov 13;24(1):638. doi: 10.1186/s12872-024-04319-7.
2024/11/14
Assessing the causal associations of atrial fibrillation with serum uric acid level and gout: insights from a bidirectional mendelian randomization study
Zhu S, Zhang M, Cheng S, Wang C, Deng F.
-
Zhonghua Yi Xue Za Zhi. 2024 Nov 19;104(43):3985-3988. doi: 10.3760/cma.j.cn112137-20240713-01598.
2024/11/14
[Analysis of a family with hypouricemia due to type Ⅰ xanthinuria]
Wang XY, Wang YJ, Zhou YK.
-
J Agric Food Chem. 2024 Nov 27;72(47):26514-26523. doi: 10.1021/acs.jafc.4c07574. Epub 2024 Nov 13.
2024/11/13
Insight into Sequential Extrusion and Cysteine Treatment for Improving Rheological Characteristics and In Vitro Digestibility of Whey Protein Isolate
Zhang R, Mu Z, Xu H, Yang N, Bilawal A, Jiang Z, Hou J.
-
Orphanet J Rare Dis. 2024 Nov 11;19(1):422. doi: 10.1186/s13023-024-03441-1.
2024/11/13
Effectiveness and safety of enzyme replacement therapy in the treatment of Fabry disease: a Chinese monocentric real-world study
Liu Y, Li Y, Li P, Zhang S, Zhiqing Z.
-
Sci Rep. 2024 Nov 11;14(1):27605. doi: 10.1038/s41598-024-79350-x.
2024/11/13
Phyllanthi Fructus ameliorates hyperuricemia and kidney injure via inhibiting uric acid synthesis, modulating urate transporters, and alleviating inflammation
Liang S, Xu D, Wu J, Jiang Q, Zeng Y.
-
J Ethnopharmacol. 2024 Nov 9;338(Pt 2):119069. doi: 10.1016/j.jep.2024.119069. Online ahead of print.
2024/11/13
Anti-inflammatory effects and mechanism of Plantago asiatica L. and Lonicera japonica Thunb. extracts based on canine and feline kidney cell models
Liu T, Bai H, Wang H, Li Y, Wang Z.
-
J Agric Food Chem. 2024 Nov 20;72(46):25879-25894. doi: 10.1021/acs.jafc.4c05845. Epub 2024 Nov 11.
2024/11/13
Functional Food Potential of Chrysanthemum morifolium, Perilla frutescens, and Sophora japonica in Managing Hyperuricemia through Dual Enzyme Inhibition
Chen KL, Xie DD, Luo MP, Liu B, Li Y, Zhao YJ, Zhao XX, Pei JM, Ding YG, Feng ZP, Wang B, Zhang XG.
-
iScience. 2024 Oct 16;27(11):111186. doi: 10.1016/j.isci.2024.111186. eCollection 2024 Nov 15.
2024/11/13
Kaempferol attenuates hyperuricemia combined with gouty arthritis via urate transporters and NLRP3/NF-κB pathway modulation
Huang Y, Li C, Xu W, Li F, Hua Y, Xu C, Wu C, Wang Y, Zhang X, Xia D.
-
Pharmacol Res Perspect. 2024 Dec;12(6):e70032. doi: 10.1002/prp2.70032.
2024/11/13
An integrated population pharmacokinetic model of febuxostat in pediatric patients with hyperuricemia including gout and adult population of healthy subjects and patients with renal dysfunction
Iwama R, Nishida K, Ishii D, Iijima T.
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Nan Fang Yi Ke Da Xue Xue Bao. 2024 Oct 20;44(10):2024-2032. doi: 10.12122/j.issn.1673-4254.2024.10.21.
2024/11/13
[Molecular mechanism of high-altitude hypoxia-induced lipid metabolism disorder in mouse spleen tissue]
Cui C, Xu Y, Tang C, Jiang J, Hu Y, Shuang J.
-
SLAS Discov. 2024 Nov 8;29(8):100193. doi: 10.1016/j.slasd.2024.100193. Online ahead of print.
2024/11/13
The development of a novel high-throughput membrane potential assay and a solid-supported membrane (SSM)-based electrophysiological assay to study the pharmacological inhibition of GLUT9/SLC2A9 isoforms in a drug discovery program
Pommereau A, Sassone F, Poli A, De Silvestris M, Scarabottolo L, Zuschlag Y, Licher T, Bärenz F.
-
Hum Cell. 2024 Nov 10;38(1):15. doi: 10.1007/s13577-024-01128-0.
2024/11/13
Identification of novel gout loci from trans-ethnic meta-analysis of serum urate level
Kawamura Y, Nakayama A, Nakatochi M, Aoki Y, Toyoda Y, Nakamura T, Shimizu S, Matsuo K, Shinomiya N, Matsuo H; for Japan Gout Genomics Consortium (Japan Gout).
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Metabolomics. 2024 Nov 9;20(6):127. doi: 10.1007/s11306-024-02194-z.
2024/11/13
Regulation of ROS metabolism in macrophage via xanthine oxidase is associated with disease progression in pulmonary tuberculosis
Liu R, Zhang F, Li S, Liu Q, Pang Y, Li L.
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Allergy Asthma Proc. 2024 Nov 1;45(6):e93-e100. doi: 10.2500/aap.2024.45.240086.
2024/11/13
COVID-19 and severe cutaneous allergic reactions to sulfonamides
Deng E, Craig TJ, Nguyen DV, Al-Shaikhly T.
-
J Med Chem. 2024 Nov 28;67(22):19966-19987. doi: 10.1021/acs.jmedchem.4c01260. Epub 2024 Nov 8.
2024/11/13
Recent Progress and Future Perspectives on Anti-Hyperuricemic Agents
Sun Z, Zhang X, Zhao Z, Li X, Pang J, Chen J.
-
Ther Umsch. 2024 Sep;81(5):160-163. doi: 10.23785/TU.2024.05.004.
2024/11/13
[Therapy of gout in 2024]
Forster A.
-
Ther Umsch. 2024 Sep;81(5):164-167. doi: 10.23785/TU.2024.05.005.
2024/11/13
[Gout and Nutrition]
Ankli B.
-
Ther Umsch. 2024 Sep;81(5):168-171. doi: 10.23785/TU.2024.05.006.
2024/11/13
Advances in treatment of hyperuricemia and gout
Dumusc A, So A.
-
Elife. 2024 Nov 7;13:e100068. doi: 10.7554/eLife.100068.
2024/11/12
Host-derived Lactobacillus plantarum alleviates hyperuricemia by improving gut microbial community and hydrolase-mediated degradation of purine nucleosides
Fu Y, Luo XD, Li JZ, Mo QY, Wang X, Zhao Y, Zhang YM, Luo HT, Xia DY, Ma WQ, Chen JY, Wang LH, Deng QY, Ben L, Kashif Saleemi M, Jiang XZ, Chen J, Miao K, Lin ZP, Zhang P, Ye H, Cao QY, Zhu YW, Yang L, Tu Q, Wang W.
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Ann Med. 2024 Dec;56(1):2423789. doi: 10.1080/07853890.2024.2423789. Epub 2024 Nov 7.
2024/11/12
The identification and prediction of atrial fibrillation in coronary artery disease patients: a multicentre retrospective study based on Bayesian network
Jian J, Zhang L, He S, Wu W, Zhang Y, Jian C, Xie M, Wang T, Liang B, Xiong X.
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Front Pharmacol. 2024 Oct 23;15:1478381. doi: 10.3389/fphar.2024.1478381. eCollection 2024.
2024/11/12
Febuxostat-induced agranulocytosis in a pediatric hematopoietic stem cell transplant recipient: Case Report and literature review
Curci D, Braidotti S, Maximova N.
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Arch Rheumatol. 2024 Aug 24;39(3):393-403. doi: 10.46497/ArchRheumatol.2024.10486. eCollection 2024 Sep.
2024/11/12
Gout and erectile dysfunction: Increased carotid intima-media thickness is independently associated with greater likelihood for erectile dysfunction
Yigit E, Yasar S, Can M, Bayraktar Z.
-
Clin Lab. 2024 Nov 1;70(11). doi: 10.7754/Clin.Lab.2024.240601.
2024/11/09
A Case of Abnormal Elevation of Serum CA 72-4 Caused by Colchicine
Li G, Lu T.
-
Food Chem. 2025 Feb 1;464(Pt 3):141864. doi: 10.1016/j.foodchem.2024.141864. Epub 2024 Nov 1.
2024/11/07
In silico identification and experimental validation of two types of angiotensin-converting enzyme (ACE) and xanthine oxidase (XO) milk inhibitory peptides
Li Z, Zhang W, Abubaker MA, Shu Q, Liu Y.
-
Rheumatology (Oxford). 2024 Nov 6:keae616. doi: 10.1093/rheumatology/keae616. Online ahead of print.
2024/11/06
An Artificial Intelligence-Based Gout Management System Reduced Chronic Kidney Disease Incident and Improved Target Serum Urate Achievement
Qi H, Lu J, Dalbeth N, Sun M, Liu Z, Ji X, Ji A, Wang C, Sun W, Li X, He Y, Cui L, Han L, Chen Y, Yan F, Zhang Y, Terkeltaub R, Li C.
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Ther Drug Monit. 2024 Nov 6. doi: 10.1097/FTD.0000000000001265. Online ahead of print.
2024/11/06
Untangling the Exposure-Response Relationship of Allopurinol in the Setting of Chronic Kidney Disease and Diuretic Use: Implications for Dosing
Hishe HZ, Stocker SL, Stamp LK, Dalbeth N, Merriman TR, Wright DFB.
-
G Ital Nefrol. 2024 Oct 9;41(Suppl 83):2024-S83.
2024/11/06
[Hyperuricemia in Chronic Kidney Disease: To Treat or Not to Treat?]
Manganaro M.
-
Cent Nerv Syst Agents Med Chem. 2024 Nov 4. doi: 10.2174/0118715249331487241021053730. Online ahead of print.
2024/11/06
Antidepressant Potential of Hispidulin Present in S. barbata D. Don: Mechanistic Insights through Neurochemical and Behavioral Assessments
Pannu A, Goyal RK, Goswami S.
-
ACR Open Rheumatol. 2024 Nov 5. doi: 10.1002/acr2.11759. Online ahead of print.
2024/11/06
Gout Flare Burden in the United States: A Multiyear Cross-Sectional Survey Study
Singh JA, Morlock A, Morlock R.
-
J Transl Med. 2024 Nov 5;22(1):999. doi: 10.1186/s12967-024-05800-9.
2024/11/06
Gut commensal Parabacteroides distasonis exerts neuroprotective effects in acute ischemic stroke with hyperuricemia via regulating gut microbiota-gut-brain axis
Wei H, Zhan L, Lv X, Lin Y, Zheng J, Yang W, Liu J, Sun J, Chen S.
-
Cell Death Dis. 2024 Nov 6;15(11):795. doi: 10.1038/s41419-024-07177-5.
2024/11/06
Metformin improves HPRT1-targeted purine metabolism and repairs NR4A1-mediated autophagic flux by modulating FoxO1 nucleocytoplasmic shuttling to treat postmenopausal osteoporosis
Yang K, Wang X, Zhang C, Liu D, Tao L.
-
Aust J Gen Pract. 2024 Nov;53(11):864-871. doi: 10.31128/AJGP-09-23-6980.
2024/11/05
How is gout currently managed, and is there interest in changing the way we deliver care? A qualitative exploratory study
Hoon E, Edwards J, Robinson P, Rowett D, Stocks N, Keen HI, Hill CL.
-
Sci Rep. 2024 Nov 4;14(1):26646. doi: 10.1038/s41598-024-77802-y.
2024/11/05
Association between neutrophil-percentage-to-albumin ratio (NPAR) and metabolic syndrome risk: insights from a large US population-based study
Ji W, Li H, Qi Y, Zhou W, Chang Y, Xu D, Wei Y.
-
Sci Rep. 2024 Nov 4;14(1):26675. doi: 10.1038/s41598-024-76970-1.
2024/11/05
Association of serum uric acid with all-cause and cardiovascular mortality in cardiovascular disease patients
Lv YL, Liu YM, Dong KX, Ma XB, Qian L.
-
Pak J Pharm Sci. 2024 Sep;37(5):1151-1161.
2024/11/04
Novel pyrimidine derivatives and black cumin as xanthine oxidase inhibitors: Synthesis, docking study and formulation
Ahjel SW, Humadi SS, Mohamed Awad S, El-Shehry MF, Mansour YE, El-Rashedy AAE.
-
J Inflamm Res. 2024 Oct 29;17:7913-7927. doi: 10.2147/JIR.S485979. eCollection 2024.
2024/11/04
Alterations of Hepatic Lipidome Occur in a Gouty Model: A Shotgun Lipidomics Study
Xu X, Jin W, Song J, Hu X, Lu L, Zhang J, Hu C.
-
World J Gastroenterol. 2024 Oct 28;30(40):4404-4410. doi: 10.3748/wjg.v30.i40.4404.
2024/11/04
Elucidating the role of gut microbiota dysbiosis in hyperuricemia and gout: Insights and therapeutic strategies
Singh AK, Durairajan SSK, Iyaswamy A, Williams LL.
-
Front Endocrinol (Lausanne). 2024 Oct 18;15:1424070. doi: 10.3389/fendo.2024.1424070. eCollection 2024.
2024/11/04
Uric acid is associated with increased risk of myocardial infarction: results from NHANES 2009-2018 and bidirectional two-sample Mendelian randomization analysis
Deng T, Liu X.
-
Biotechnol Appl Biochem. 2024 Nov 3. doi: 10.1002/bab.2690. Online ahead of print.
2024/11/04
Investigation of resveratrol as a xanthine oxidase inhibitor: Mechanistic insights and therapeutic implications for gout and hyperuricemia
Chen J, Chen J, Feng B, Ning M, Wu W, Zou S.
-
Joint Bone Spine. 2024 Oct 28;92(1):105796. doi: 10.1016/j.jbspin.2024.105796. Online ahead of print.
2024/11/04
Pediatrics hyperuricemia in clinical practice: A retrospective analysis in 1753 children and adolescents with hyperuricemia
Stiburkova B, Lukesova M, Zeman J.
-
Food Chem Toxicol. 2024 Nov 1;194:115087. doi: 10.1016/j.fct.2024.115087. Online ahead of print.
2024/11/04
Hepatoprotective effects of the xanthine oxidase inhibitor Febuxostat against thioacetamide-induced liver injury in rats: The role of the Nrf2/ HO-1 and TLR4/ NF-κB pathways
Abdelrahman RS, Abdelmageed ME.
-
Int J Biol Macromol. 2024 Nov 1;283(Pt 1):137152. doi: 10.1016/j.ijbiomac.2024.137152. Online ahead of print.
2024/11/04
Structural characterization and anti-hyperuricemic effect of a mannogalactan from Armillariella tabescens mycelium
Guo W, Zhang J, Deng H, Hao Y, Chen H, Li Y, Zhang W, Zhang M, Chen Y.
-
Int J Biol Macromol. 2024 Nov 1;282(Pt 5):137112. doi: 10.1016/j.ijbiomac.2024.137112. Online ahead of print.
2024/11/04
Polysaccharide isolated from Dioscorea septemloba improves hyperuricemia and alleviates renal fibrosis through gut-kidney axis in mice
Wang Z, Wu G, Niu T, Guo Y, Wang C, Wang X, Yu J.
-
Open Heart. 2024 Oct 31;11(2):e002830. doi: 10.1136/openhrt-2024-002830.
2024/11/04
Hyperuricaemia elevates risk of short-term readmission and mortality in patients with heart failure
Rao J, Lai R, Jiang L, Wen W, Chen H.
-
Nutr Metab Insights. 2024 Oct 16;17:11786388241288668. doi: 10.1177/11786388241288668. eCollection 2024.
2024/11/04
Hyperuricemia and Associated Factors in Adult Cardiac Patients in Western Oromia, Ethiopia
Addisu B, Sefew AT, Milkit A, Hika A, Kelem A, Hirigo AT.
-
J Transl Med. 2024 Oct 31;22(1):983. doi: 10.1186/s12967-024-05778-4.
2024/11/04
Hyperuricemia suppresses lumican, exacerbating adverse remodeling after myocardial infarction by promoting fibroblast phenotype transition
Zhuang Z, Liu A, Zhang J, Han S, Tang L, Yu T, Shi Y, Li H, Yang H, Bai P, Tang Y.
-
BMC Cardiovasc Disord. 2024 Nov 1;24(1):613. doi: 10.1186/s12872-024-04297-w.
2024/11/02
Waist-to-hip ratio as a contributor associated with higher atherosclerotic cardiovascular disease risk assessment in patients with diabetes: a cross-sectional study
Rafsanjani K, Rabizadeh S, Ebrahimiantabrizi A, Asadibideshki Z, Yadegar A, Esteghamati A, Nakhjavani M, Reyhan SK.
-
BMC Cardiovasc Disord. 2024 Nov 1;24(1):614. doi: 10.1186/s12872-024-04287-y.
2024/11/02
Interaction of serum uric acid with overweight on hypertension: findings from the China Health and Nutrition Survey
Wang H, Fan JL.
-
Carbohydr Polym. 2025 Jan 1;347:122665. doi: 10.1016/j.carbpol.2024.122665. Epub 2024 Aug 27.
2024/11/02
Mechanisms of levan in ameliorating hyperuricemia: Insight into levan on serum metabolites, gut microbiota, and function in hyperuricemia rats
Xu M, Xiao H, Zou X, Pan L, Song Q, Hou L, Zeng Y, Han Y, Zhou Z.
-
Biochem Pharmacol. 2024 Oct 29;230(Pt 2):116596. doi: 10.1016/j.bcp.2024.116596. Online ahead of print.
2024/11/01
Insights into the modulatory effects of host-gut microbial xanthine co-metabolism on high-fat diet-fed mice
Chen WB, Hu GA, Dong BC, Sun HY, Lu DZ, Ru MY, Yu YL, Wang H, Wei B.

